Monaco government contributes €200,000 to childhood brain cancer clinical trials

The government of Monaco is backing the work and efforts of the Centre Scientifique de Monaco to revolutionise the treatment of brain cancer in children by offering to part fund clinical trials to the tune of €200,000.  

The Mependax (Medulloblastoma, EPENDymoma, AXitinib) clinical trial was launched in June 2023 and “repurposes” a Pfizer molecule that is already used to treat adult cancer patients to fight brain cancers in children.  

The trial, headed up by paediatric oncologist Nicolas Andre from the Timone Hospital in Marseille, will be made up of 36 patients who are currently being treated at eight different health care centres in France, and will help “to determine the effectiveness and lower toxicity of metronomic administration of axitinib in combination with reduced doses of traditional chemotherapy”. 

Results of preclinical research carried out by scientists at the Centre Scientifique de Monaco (CSM) show that axitinib, when given according to a “metronomic” plan, can be at least as effective as current therapies, whilst also having an improved toxicity profile. In real terms, this could mean cancer patients being treated with this molecule could suffer less harsh side effects. It also reduces the resistance risk in cancer treatments.  

MONACO’S CONTRIBUTION 

Christophe Robino, Monaco’s Councillor-Minister of Social Affairs and Health, alongside Adrien Baron of the Timone hospital and Denis Maccario, President of the Flavien Foundation, which has also provided significant support to the project, signed an agreement on 9th October to formalise a collaboration between the Monegasque government and the Assistance Publique des Hôpitaux de Marseille (AP-HM). 

Said Robino of the trials, “We must still reflect on the way in which we can better understand and satisfy the needs of children affected by cancer, as well as those of their families and caregivers.”  

YEARS IN THE MAKING 

The CSM have been working on targeted anti-cancer therapies for children since November 2015, using treatments that were proven effective in adults as the basis.  

The total cost of the trail is €620,000. Private donations are very welcome and can be made by clicking here

Read more about the work of the CSM and the clinical trials here: 

CSM set to revolutionise treatment of childhood cancer

 

 

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Soldiers deployed and security level at max in France following murder of Arras teacher

arras attack

France has been placed under the highest security alert level following a brutal knife attack on a school in Pas de Calais, which has left one dead and three others injured.  

On Friday 13th October, a man identified in the media as Mohammed Moguchkov entered the premises of his former high school in Arras. Reportedly armed with a concealed knife, he attacked and fatally stabbed 57-year-old teacher Dominique Bernard. A security guard, a second teacher and a cleaner were also injured, according to AFP. 

Moguchkov is believed to be in his 20s. According to press reports, he moved to France with his family from his native Chechnya as a young boy. He is understood to be Muslim and had reportedly shouted “Allahu Akbar!”, an Arabic phrase appropriated by Islamist terrorists, during the attack.  

Suspect and family known to security services

AFP reports that the suspect was already known to the French security services. A police source cited by France 24 claims that Moguchkov had been identified as a potential threat in early October and was under electronic and physical surveillance by the GDSI. Other media reports have alleged he was stopped by police the day before the attack, but there had been no grounds on which to detain and hold him.  

According to some media reports, the suspect’s family was served with an expulsion order in 2014 and taken to an airport for a flight heading to Moscow. Unspecified humanitarian organisations reportedly intervened and the family was ultimately allowed to remain. 

10 people are believed to have been arrested in connection with the attack in Arras, including the younger brother of the main suspect.

Jean-François Ricard, France’s anti-terrorist prosecutor, revealed at a press conference following the incident that Moguchkov’s elder brother is currently in prison for two terrorism-linked charges. 

A statement released by the prosecutor’s office following Friday’s attack reads, “The national anti-terrorist prosecutor’s office has opened an investigation for the following: murder in relation to a terrorist initiative; attempted murder in relation to a terrorist initiative; association of terrorist wrongdoer in preparation for crimes against people.” 

“Barbarity of Islamist terrorism” 

Speaking to the media, French President Emmanuel Macron has called the attack an example of the “barbarity of Islamist terrorism”. He also revealed that another attempted attack in a separate region of France had recently been prevented by security forces.  

France’s Interior Minister Gérald Darmanin has suggested that there is “probably a link between what’s happening in the Middle East and this incident [in Arras].”  

Nationwide, France has since increased its security alert to the highest level. 7,000 soldiers from the specialist Operation Sentinelle have also been deployed to areas of the country deemed to be sensitive to potential terrorist attacks.  

The victim: Dominique Bernard 

Exactly three years on from a similar attack on Samuel Paty, a history and geography teacher who was beheaded by a Chechen refugee near Paris, schools and education establishments across France paid tribute to the brave victim of this most recent killing on Monday 16th October.  

“The teacher who was killed intervened first. He undoubtedly saved many lives,” said Macron of Bernard’s actions. “His seriously injured colleague and the staff who were also seriously injured showed the same courage. But so did the headteacher and many others in that moment.” 

 

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Stelios Foundation and Hellenic Community of Monaco raise €60,000 for The Hellenic Initiative

The Stelios Philanthropic Foundation and the Hellenic Community of Monaco came together earlier this month to host a special event in Monaco that introduced the important work of The Hellenic Initiative to empower the Greek diaspora and provide support to the country’s economic and humanitarian development.  

On Thursday 12th October, the Monaco headquarters of the Stelios Philanthropic Foundation on Quai Antoine 1er set the stage for a series of enlightening speeches delivered by Sir Stelios, the founder of easyJet and his eponymous foundation, and The Hellenic Initiative’s (THI) co-founder and Board President, George Stamas.  

This event was orchestrated through the dedicated efforts of Sophia Vaharis Tsouvelekakis, President of the Hellenic Community of Monaco. Another notable local figure who attended was Michael Printzos, the Country Head of the THI.  

The evening was a celebration of THI’s remarkable work, and a testament to the power of collaboration and unity it can command in the name of humanitarian and economic development. 

To date, THI has provided some €20.5 million in direct grants to more than 100 organisations thanks to a vast network of over 4,500 global contributors. 

Guests attending the event in Monaco were asked to make a minimum donation of €100 to THI, but the final amount raised through voluntary donations reached an impressive €30,000.  

The Stelios Philanthropic Foundation matched these contributions, doubling the sum to an incredible €60,000, which will go towards supporting the various admirable causes backed by THI.  

A Monaco chapter of The Hellenic Initiative 

By working together to organise and host the recent event, the Stelios Philanthropic Foundation and the Hellenic Community of Monaco demonstrated that collective efforts can have a significant and thoroughly positive impact. 

The next step in this collaboration will be to create a chapter of THI in Monaco, as “forming something permanent in Monaco is something that is very unique to us,” said Stamas on the night.  

“If the spirit carries on, we have something everlasting,” he concluded. 

For more information, please click here

 

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